Sanctuary: Main Research Broken Sonic Locks
In Main Research (the room with the Caretaker drone), when using the Echo Visor to destroy the sonic emitters, if you should leave the room before destroying all the emitters, upon returning to the room you will find all the emitters destroyed but the door still in place.
If you save after destroying some of the emitters, the only way to progress will be by performing a "Kip Dash" or "Roll Jump" across the Watch Station Access.
You will also need to either skip the Ing Hive keys, or use the no space jump method for the 3rd Ing Hive Temple Key (Aerial Training Site). See the noSJ run videos by 'tjp7154' and 'Mr Potter'. tj's any% Mr P's max%